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Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.
Signs and symptoms of overdosage with promethazine HCl range from mild depression of the central nervous system and cardiovascular system to profound hypotensionrespiratory depressionunconsciousnessand sudden deathOther reported reactions include hyperreflexiahypertoniaataxiaathetosisand extensor-plantar reflexesBabinski reflex
Use of Phenergan Tablets and Suppositories in patients with compromised respiratory functione.gCOPDsleep apneashould be avoided.
A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant SyndromeNMShas been reported in association with promethazine HCl alone or in combination with antipsychotic drugsClinical manifestations of NMS are hyperpyrexiamuscle rigidityaltered mental status and evidence of autonomic instabilityirregular pulse or blood pressuretachycardiadiaphoresis and cardiac dysrhythmias
POSTMARKETING CASES OF RESPIRATORY DEPRESSIONINCLUDING FATALITIESHAVE BEEN REPORTED WITH USE OF Phenergan IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGEA WIDE RANGE OF WEIGHT-BASED DOSES OF Phenergan HAVE RESULTED IN RESPIRATORY DEPRESSION IN THESE PATIENTS.
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