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Figure sales market share of isoniazid by application 2012-2017 .

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Information about Isoniazid.

Isoniazid comes as a tablet and a solutionliquidto take by mouth without foodIsoniazid is usually is taken once a dayit may also be taken onetwoor three times weeklyTake isoniazid at around the same time every scheduled dayFollow the directions on your prescription label carefullyand ask your doctor or pharmacist to explain any part you do not understandTake isoniazid exactly as directedDo not take more or less of it or take it more often than prescribed by your doctor.

Isoniazidthe hydrazide of isonicotinic acidis highly bactericidal against replicating tubercle bacilli.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Isoniazid is a prodrug and must be activated by bacterial catalaseSpecficiallyactivation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complexOnce activatedisoniazid inhibits the synthesis of mycoloic acidsan essential component of the bacterial cell wallAt therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organismsSpecifically isoniazid inhibits InhAthe enoyl reductase from Mycobacterium tuberculosisby forming a covalent adduct with the NAD cofactorIt is the INH-NAD adduct that acts as a slowtight-binding competitive inhibitor of InhA.

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